Probing and manipulating noncovalent interactions in functional polymeric systems
Noncovalent interactions, which usually feature tunable strength, reversibility, and
environmental adaptability, have been recognized as driving forces in a variety of biological …
environmental adaptability, have been recognized as driving forces in a variety of biological …
Protein-based biological materials: Molecular design and artificial production
Polymeric materials produced from fossil fuels have been intimately linked to the
development of industrial activities in the 20th century and, consequently, to the …
development of industrial activities in the 20th century and, consequently, to the …
Peptide-based coacervates as biomimetic protocells
Coacervates are condensed liquid-like droplets formed by liquid–liquid phase separation of
molecules through multiple weak associative interactions. In recent years it has emerged …
molecules through multiple weak associative interactions. In recent years it has emerged …
How Droplets Can Accelerate Reactions─ Coacervate Protocells as Catalytic Microcompartments
IBA Smokers, BS Visser, AD Slootbeek… - Accounts of Chemical …, 2024 - ACS Publications
Conspectus Coacervates are droplets formed by liquid–liquid phase separation (LLPS) and
are often used as model protocells–primitive cell-like compartments that could have aided …
are often used as model protocells–primitive cell-like compartments that could have aided …
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics
Biomacromolecules are highly promising therapeutic modalities to treat various diseases.
However, they suffer from poor cellular membrane permeability, limiting their access to …
However, they suffer from poor cellular membrane permeability, limiting their access to …
Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof.
EW Martin, AS Holehouse - Emerging topics in life sciences, 2020 - europepmc.org
Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …
Peptide self-assembly through liquid-liquid phase separation
C Yuan, Q Li, R **ng, J Li, X Yan - Chem, 2023 - cell.com
Peptide self-assembly provides an innovative strategy for not only establishing an ideal
research model to understand life phenomena but also for constructing sophisticated …
research model to understand life phenomena but also for constructing sophisticated …
Hydrogen-bonds mediate liquid-liquid phase separation of mussel derived adhesive peptides
Marine mussels achieve strong underwater adhesion by depositing mussel foot proteins
(Mfps) that form coacervates during the protein secretion. However, the molecular …
(Mfps) that form coacervates during the protein secretion. However, the molecular …
Histidine as a key modulator of molecular self-assembly: Peptide-based supramolecular materials inspired by biological systems
Histidine, a versatile proteinogenic amino acid, plays a broad range of roles in all living
organisms and behaves as a key mediator of the interactions of biomolecules with inorganic …
organisms and behaves as a key mediator of the interactions of biomolecules with inorganic …
Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior
Phase separation of intrinsically disordered proteins (IDPs) commonly underlies the
formation of membraneless organelles, which compartmentalize molecules intracellularly in …
formation of membraneless organelles, which compartmentalize molecules intracellularly in …