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Why does obesity cause diabetes?
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …
The cellular and functional complexity of thermogenic fat
Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …
in the form of heat. These thermogenic fat cells were originally considered to function solely …
Adipogenesis and metabolic health
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity
Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …
Adipose tissue fibrosis in obesity: etiology and challenges
Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …
associated with comorbidity development. In addition to increased fat mass, obesity induces …
Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
A Hammarstedt, S Gogg, S Hedjazifar… - Physiological …, 2018 - journals.physiology.org
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …
However, it has a limited ability to expand by recruiting and/or differentiating available …
Angiogenesis in adipose tissue and obesity
While most tissues exhibit their greatest growth during development, adipose tissue is
capable of additional massive expansion in adults. Adipose tissue expandability is …
capable of additional massive expansion in adults. Adipose tissue expandability is …
[HTML][HTML] Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …
Targeting adipose tissue in the treatment of obesity-associated diabetes
Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …
An integrated view of immunometabolism
The worldwide obesity epidemic has emerged as a major cause of insulin resistance and
Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the …
Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the …