Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental carcinogens and
metabolized by a variety of xenobiotic-metabolizing enzymes such as cytochrome P450 …

One of the greatest challenges facing human geneticists is the identification and
characterization of susceptibility genes for common complex multifactorial human diseases …

Abstract Using the International Project on Genetic Susceptibility to Environmental
Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) …

Tobacco use is causally associated with cancers of the lung, larynx, mouth, esophagus,
kidneys, urinary tract, and possibly, breast. Major classes of carcinogens present in tobacco …

It is well recognized that most medications exhibit wide interpatient variability in their efficacy
and toxicity. For many medications, these interindividual differences are due in part to …

Objective The frequency of functionally important mutations and alleles of genes coding for
xenobiotic metabolizing enzymes shows a wide ethnic variation. However, little is known of …

In this review, an overview is presented of the current knowledge of genetic polymorphisms
of four of the most important enzyme families involved in the metabolism of xenobiotics, that …

Myeloperoxidase is a signature enzyme of polymorphonuclear neutrophils in mice and
humans. Being a component of circulating white blood cells, myeloperoxidase plays multiple …

The major known risk factors for female breast cancer are associated with prolonged
exposure to increased levels of oestrogen. The predominant theory relates to effects of …