Virulence Factors in Hypervirulent Klebsiella pneumoniae

J Zhu, T Wang, L Chen, H Du - Frontiers in microbiology, 2021 - frontiersin.org
Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the
Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae …

Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae

RM Martin, MA Bachman - Frontiers in cellular and infection …, 2018 - frontiersin.org
Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …

Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study

F Hu, Y Pan, H Li, R Han, X Liu, R Ma, Y Wu… - Nature …, 2024 - nature.com
Epidemiological knowledge of circulating carbapenem-resistant Klebsiella pneumoniae
(CRKP) is needed to develop effective strategies against this public health threat. Here we …

A genomic surveillance framework and genoty** tool for Klebsiella pneumoniae and its related species complex

MMC Lam, RR Wick, SC Watts, LT Cerdeira… - Nature …, 2021 - nature.com
Klebsiella pneumoniae is a leading cause of antimicrobial-resistant (AMR) healthcare-
associated infections, neonatal sepsis and community-acquired liver abscess, and is …

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

K Atarashi, W Suda, C Luo, T Kawaguchi, I Motoo… - Science, 2017 - science.org
Intestinal colonization by bacteria of oral origin has been correlated with several negative
health outcomes, including inflammatory bowel disease. However, a causal role of oral …

Klebsiella pneumoniae: going on the offense with a strong defense

MK Paczosa, J Mecsas - Microbiology and molecular biology …, 2016 - journals.asm.org
Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health

KE Holt, H Wertheim, RN Zadoks, S Baker… - Proceedings of the …, 2015 - pnas.org
Klebsiella pneumoniae is now recognized as an urgent threat to human health because of
the emergence of multidrug-resistant strains associated with hospital outbreaks and …

Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver

X Huang, X Li, H An, J Wang, M Ding, L Wang… - PLoS …, 2022 - journals.plos.org
Polysaccharide capsule is the main virulence factor of K. pneumoniae, a major pathogen of
bloodstream infections in humans. While more than 80 capsular serotypes have been …

Identification of Klebsiella capsule synthesis loci from whole genome data

KL Wyres, RR Wick, C Gorrie, A Jenney… - Microbial …, 2016 - microbiologyresearch.org
Klebsiella pneumoniae is a growing cause of healthcare-associated infections for which
multi-drug resistance is a concern. Its polysaccharide capsule is a major virulence …

Molecular Pathogenesis of Klebsiella Pneumoniae

B Li, Y Zhao, C Liu, Z Chen, D Zhou - Future microbiology, 2014 - Taylor & Francis
Typical Klebsiella pneumoniae is an opportunistic pathogen, which mostly affects those with
weakened immune systems and tends to cause nosocomial infections. A subset of …