Human organoids, self-organized and differentiated from homogenous pluripotent stem cells
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …

Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical
applications due to their suitable biological properties and tunable physical characteristics …

Engineered tissues need a vascular network to supply cells with nutrients and oxygen after
implantation. A network that can connect to the vasculature of the patient after implantation …

Purpose Non-healing or slow healing chronic wounds are among serious complications of
diabetes that eventually result in amputation of limbs and increased morbidities and …

Creating vascular networks in tissues is crucial for tissue engineering. Although recent
studies have demonstrated the formation of vessel-like structures in a tissue model, long …

Abstract Development of a vascularized tissue is one of the key challenges for the
successful clinical application of tissue engineered constructs. Despite the significant efforts …

Rapid progress in tissue engineering research in past decades has opened up vast
possibilities to tackle the challenges of generating tissues or organs that mimic native …

Microfluidics is invaluable for studying microvasculature, development of organ-on-chip
models and engineering microtissues. Microfluidic design can cleverly control geometry …

Only a few engineered tissues—skin, cartilage, bladder—have achieved clinical success,
and biomaterials designed to replace more complex organs are still far from commercial …

Engineering of organized vasculature is a crucial step in the development of functional and
clinically relevant tissue constructs. A number of previous techniques have been proposed …