Aurora kinase belongs to serine/threonine kinase family which controls cell division.
Therapeutic inhibition of Aurora kinase showed great promise as probable anticancer …

Pyrazole has been the topic of interest for thousands of researchers across the world
because of its wide spectrum pharmacological activities. Various structural modifications of …

Three-dimensional nitrogen-rich bridged ring systems are of great interest in drug discovery
owing to their distinctive physicochemical and structural properties. However, synthetic …

Aurora kinases are essential for cell division and are frequently misregulated in human
cancers. Based on their potential as cancer therapeutics, a plethora of small molecule …

Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)
halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently …

Pharmacologic inhibition of the oncogenic protein kinases using small molecules is a
promising strategy to combat several human malignancies. CDK1 is an example of such a …

The development of an efficient approach to construct fused polycyclic systems bearing a
quaternary carbon center represents a great challenge to synthetic chemistry. Herein, we …

An Ir (III)-catalyzed double C–H activation strategy has been developed for the synthesis of
highly rigid spiro frameworks by means of ortho-functionalization of 2-aryl phthalazinediones …

Phthalazine, a structurally and pharmacologically versatile nitrogen-containing heterocycle,
has gained more attention from medicinal chemists in the design and synthesis of novel …

Aurora A kinase, a member of the Aurora kinase family, is frequently overexpressed in
various human cancers. In addition, Overexpression of Aurora A kinase is associated with …