The various applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical
and life sciences demand a range of methods for their installation in an array of molecular …

Activation of inert chemical bonds by transition metal complexes is an area of utmost
importance. Efficient bond activation can provide a leading entry to successful catalytic …

The catalytic functionalization of unreactive C− H bonds has recently brought a revolution in
synthetic methodologies for the production of pharmaceuticals and natural products and for …

Synthetically useful functional groups, including ketones, amides, carbamates, carboxylic
acids, aldehydes or ethers, have been identified as weakly coordinating directing groups in …

The metal-catalysed successive activation and functionalisation of sp2 C–H bonds is the at
heart of synthetic innovations for the development of C–C bond cross-coupling processes …

Until recently, computational tools were mainly used to explain chemical reactions after
experimental results were obtained. With the rapid development of software and hardware …

Deuterated and tritiated analogs of drugs are valuable compounds for pharmaceutical and
medicinal chemistry. In this work, we present a novel hydrogen isotope exchange reaction of …

Precise deuterium incorporation with controllable deuterated sites is extremely desirable.
Here, a facile and efficient electrocatalytic deuterodehalogenation of halides using D2O as …

Ligands in coordination chemistry and homogeneous catalysis are traditionally “static”
spectators that do not actively participate in the catalytic cycle. However, such classic …

The preparation of deuterated alkenes via electrochemistry from a readily available
deuterated source has the advantages of mild reaction conditions, sustainability, and cost …