Solid-state NMR: Methods for biological solids

S Ahlawat, KR Mote, NA Lakomek… - Chemical Reviews, 2022 - ACS Publications
In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

Multiplexing experiments in NMR and multi-nuclear MRI

Ē Kupče, KR Mote, A Webb, PK Madhu… - Progress in Nuclear …, 2021 - Elsevier
Multiplexing NMR experiments by direct detection of multiple free induction decays (FIDs) in
a single experiment offers a dramatic increase in the spectral information content and often …

CAPITO—a web server-based analysis and plotting tool for circular dichroism data

C Wiedemann, P Bellstedt, M Görlach - Bioinformatics, 2013 - academic.oup.com
Motivation: Circular dichroism (CD) spectroscopy is one of the most versatile tools to study
protein folding and to validate the proper fold of purified proteins. Here, we aim to provide a …

Sequential backbone assignment based on dipolar amide-to-amide correlation experiments

SQ **ang, K Grohe, P Rovó, SK Vasa, K Giller… - Journal of biomolecular …, 2015 - Springer
Proton detection in solid-state NMR has seen a tremendous increase in popularity in the last
years. New experimental techniques allow to exploit protons as an additional source of …

PHRONESIS: A One‐Shot Approach for Sequential Assignment of Protein Resonances by Ultrafast MAS Solid‐State NMR Spectroscopy

T Gopinath, VS Manu, DK Weber, G Veglia - ChemPhysChem, 2022 - Wiley Online Library
Solid‐state NMR (ssNMR) spectroscopy has emerged as the method of choice to analyze
the structural dynamics of fibrillar, membrane‐bound, and crystalline proteins that are …

Multi-receiver solid-state NMR using polarization optimized experiments (POE) at ultrafast magic angle spinning

T Gopinath, DK Weber, G Veglia - Journal of biomolecular NMR, 2020 - Springer
Ultrafast magic angle spinning (MAS) technology and 1 H detection have dramatically
enhanced the sensitivity of solid-state NMR (ssNMR) spectroscopy of biopolymers. We …

Orphan spin operators enable the acquisition of multiple 2D and 3D magic angle spinning solid-state NMR spectra

T Gopinath, G Veglia - The Journal of chemical physics, 2013 - pubs.aip.org
We propose a general method that enables the acquisition of multiple 2D and 3D solid-state
NMR spectra for U-13 C, 15 N-labeled proteins. This method, called MEIOSIS (Multiple …

A suite of pulse sequences based on multiple sequential acquisitions at one and two radiofrequency channels for solid-state magic-angle spinning NMR studies of …

K Sharma, PK Madhu, KR Mote - Journal of biomolecular NMR, 2016 - Springer
One of the fundamental challenges in the application of solid-state NMR is its limited
sensitivity, yet a majority of experiments do not make efficient use of the limited polarization …

Proton-detected polarization optimized experiments (POE) using ultrafast magic angle spinning solid-state NMR: Multi-acquisition of membrane protein spectra

T Gopinath, G Veglia - Journal of Magnetic Resonance, 2020 - Elsevier
Proton-detected solid-state NMR (ssNMR) spectroscopy has dramatically improved the
sensitivity and resolution of fast magic angle spinning (MAS) methods. While relatively …

Access to side-chain carbon information in deuterated solids under fast MAS through non-rotor-synchronized mixing

N Kulminskaya, SK Vasa, K Giller, S Becker… - Chemical …, 2016 - pubs.rsc.org
We demonstrate the accessibility of aliphatic 13C side chain chemical shift sets for solid-
state NMR despite perdeuteration and fast MAS using isotropic, non-rotor-synchronized 13C …