Atomic force microscopy-based mechanobiology

M Krieg, G Fläschner, D Alsteens, BM Gaub… - Nature Reviews …, 2019‏ - nature.com
Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Imaging modes of atomic force microscopy for application in molecular and cell biology

YF Dufrêne, T Ando, R Garcia, D Alsteens… - Nature …, 2017‏ - nature.com
Atomic force microscopy (AFM) is a powerful, multifunctional imaging platform that allows
biological samples, from single molecules to living cells, to be visualized and manipulated …

The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

V Venturini, F Pezzano, F Catala Castro, HM Häkkinen… - Science, 2020‏ - science.org
INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

The nucleus acts as a ruler tailoring cell responses to spatial constraints

AJ Lomakin, CJ Cattin, D Cuvelier, Z Alraies, M Molina… - Science, 2020‏ - science.org
INTRODUCTION The human body is a crowded place. This crowding is even more acute
when the regulation of cell growth and proliferation fails during the formation of a tumor …

Force spectroscopy of single cells using atomic force microscopy

A Viljoen, M Mathelié-Guinlet, A Ray… - Nature Reviews …, 2021‏ - nature.com
Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

The mechanics of mitotic cell rounding

AV Taubenberger, B Baum… - Frontiers in cell and …, 2020‏ - frontiersin.org
When animal cells enter mitosis, they round up to become spherical. This shape change is
accompanied by changes in mechanical properties. Multiple studies using different …

Atomic force microscopy-based characterization and design of biointerfaces

D Alsteens, HE Gaub, R Newton… - Nature Reviews …, 2017‏ - nature.com
Atomic force microscopy (AFM)-based methods have matured into a powerful nanoscopic
platform, enabling the characterization of a wide range of biological and synthetic …

Intracellular softening and increased viscoelastic fluidity during division

S Hurst, BE Vos, M Brandt, T Betz - Nature Physics, 2021‏ - nature.com
The life and death of an organism rely on correct cell division, which occurs through the
process of mitosis. Although the biochemical signalling and morphogenetic processes …

Thirty years of search and capture: The complex simplicity of mitotic spindle assembly

R Heald, A Khodjakov - Journal of Cell Biology, 2015‏ - rupress.org
Cell division is enacted by a microtubule-based, self-assembling macromolecular machine
known as the mitotic spindle. In 1986, Kirschner and Mitchison proposed that by undergoing …

Scaffold, mechanics and functions of nuclear lamins

A Buxboim, R Kronenberg‐Tenga, S Salajkova… - FEBS …, 2023‏ - Wiley Online Library
Nuclear lamins are type‐V intermediate filaments that are involved in many nuclear
processes. In mammals, A‐and B‐type lamins assemble into separate physical meshwork …