The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …

HIV-1 envelope glycoprotein [Env; trimeric (gp160) 3 cleaved to (gp120/gp41) 3] attaches
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …

The CXC chemokine CXCL12 is an important factor in physiological and pathological
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …

Abstract Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4is) are oral anti-diabetic drugs
(OADs) for the treatment of type 2 diabetes mellitus (T2DM) through inhibiting the …

Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …

The role of neutrophils in bone regeneration remains elusive. In this study, it is shown that
intramuscular implantation of interleukin‐8 (IL‐8)(commonly recognized as a chemotactic …

Chemokine receptors are critical regulators of cell migration in the context of immune
surveillance, inflammation, and development. The G protein–coupled chemokine receptor …

Cellular senescence has been perceived as a barrier against carcinogenesis. However, the
senescence-associated secretory phenotype (SASP) of senescent cells can promote …

Breast cancer is characterized by a distinct metastatic pattern involving the regional lymph
nodes, bone marrow, lung and liver. Tumour cell migration and metastasis share many …

HIV entry into CD4+ cells requires interaction with a cellular receptor, generally either CCR5
or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral …