Thanks to their amenability to both genetic and biochemical analysis, vacuoles of S.
cerevisiae are valuable models for trafficking processes to mammalian lysosomes. They …

Yeast-like and filamentous fungi contain vacuoles which are similar to mammalian
lysosomes and plant vacuoles, and have a variety of important functions in solute storage …

Nutritional immunity describes the host-driven manipulation of essential micronutrients,
including iron, zinc and manganese. To withstand nutritional immunity and proliferate within …

The transition between yeast and hyphae is crucial for regulating the commensalism and
pathogenicity in Candida albicans. The mechanisms that affect the invasion of hyphae in …

With a limited arsenal of available antifungal drugs and drug-resistance emergence,
strategies that seek to reduce Candida immune evasion and virulence could be a promising …

Filamentous hyphae of the human pathogen, C andida albicans, invade mucosal layers and
medical silicones. In vitro, hyphal tips reorient thigmotropically on contact with small …

Fungal dimorphism involves two morphologies: a unicellular yeast cell and a multicellular
hyphal form. Invasion of hyphae into human cells causes severe opportunistic infections …

Fungal vacuoles are involved in a diverse range of cellular functions, participating in cellular
homeostasis, degradation of intracellular components, and storage of ions and molecules. In …

Candida albicans is a common cause of catheter-related bloodstream infections (CR-BSI), in
part due to its strong propensity to form biofilms. Drug repurposing is an approach that might …

In fungi, as with all walled organisms, cytokinesis followed by septation marks the end of the
cell cycle and is essential for cell division and viability. For yeasts, the septal cross-wall …