The physiological role of α‐synuclein and its relationship to Parkinson's Disease

D Sulzer, RH Edwards - Journal of neurochemistry, 2019 - Wiley Online Library
The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …

Cell biology and pathophysiology of α-synuclein

J Burré, M Sharma, TC Südhof - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Mechanisms of α-synuclein induced synaptopathy in Parkinson's disease

JC Bridi, F Hirth - Frontiers in neuroscience, 2018 - frontiersin.org
Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …

The synaptic function of α-synuclein

J Burré - Journal of Parkinson's disease, 2015 - content.iospress.com
Abstract α-Synuclein is an abundant neuronal protein which localizes predominantly to
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …

[HTML][HTML] Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake

X Zhao, D Wu, X Ma, J Wang, W Hou… - Biomedicine & …, 2020 - Elsevier
With the development of biomedicine, exosomes are rapidly develo** as a new therapy
for tumors. As biological carriers, exosomes possess biological activity and can transport …

Structure, function and toxicity of alpha‐synuclein: the Bermuda triangle in synucleinopathies

A Villar‐Piqué, T Lopes da Fonseca… - Journal of …, 2016 - Wiley Online Library
Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders
characterized by the misfolding and accumulation of alpha‐synuclein aggregates that are …

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

WK Man, B Tahirbegi, MD Vrettas, S Preet… - Nature …, 2021 - nature.com
Abstract α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is
associated with Parkinson's disease. The functional role of αS is still debated, although it …

Parkinson's disease: from synaptic loss to connectome dysfunction

A Bellucci, NB Mercuri, A Venneri… - Neuropathology and …, 2016 - Wiley Online Library
Parkinson's disease (PD) is a common neurodegenerative disorder with prominent loss of
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …

[HTML][HTML] Alpha-synuclein function and dysfunction on cellular membranes

D Snead, D Eliezer - Experimental neurobiology, 2014 - ncbi.nlm.nih.gov
Alpha-synuclein is a small neuronal protein that is closely associated with the etiology of
Parkinson's disease. Mutations in and alterations in expression levels of alpha-synuclein …

Common mechanisms underlying α-synuclein-induced mitochondrial dysfunction in Parkinson's disease

T Sohrabi, B Mirzaei-Behbahani, R Zadali… - Journal of Molecular …, 2023 - Elsevier
Parkinson's disease (PD) is the most common neurological movement disorder
characterized by the selective and irreversible loss of dopaminergic neurons in substantia …