The oxytocin receptor: from intracellular signaling to behavior

B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

The integrated brain network that controls respiration

F Krohn, M Novello, RS van der Giessen, CI De Zeeuw… - Elife, 2023 - elifesciences.org
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance

HJ Grill, MR Hayes - Cell metabolism, 2012 - cell.com
This Review highlights the processing and integration performed by hindbrain nuclei,
focusing on the inputs received by nucleus tractus solitarius (NTS) neurons. These inputs …

The effects of oxytocin on eating behaviour and metabolism in humans

EA Lawson - Nature Reviews Endocrinology, 2017 - nature.com
Oxytocin, a hypothalamic hormone that is secreted directly into the brain and enters the
peripheral circulation through the posterior pituitary gland, regulates a range of physiologic …

Oxytocin reduces caloric intake in men

EA Lawson, DA Marengi, RL DeSanti, TM Holmes… - …, 2015 - Wiley Online Library
Objective Preclinical studies indicate that oxytocin is anorexigenic and has beneficial
metabolic effects. Oxytocin effects on nutrition and metabolism in humans are not well …

Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway

Y Maejima, U Sedbazar, S Suyama, D Kohno, T Onaka… - Cell metabolism, 2009 - cell.com
The hypothalamic paraventricular nucleus (PVN) functions as a center to integrate various
neuronal activities for regulating feeding behavior. Nesfatin-1, a recently discovered …

Metabolic effects of oxytocin

SE McCormack, JE Blevins, EA Lawson - Endocrine reviews, 2020 - academic.oup.com
There is growing evidence that oxytocin (OXT), a hypothalamic hormone well recognized for
its effects in inducing parturition and lactation, has important metabolic effects in both sexes …

The vagus nerve, food intake and obesity

HR Berthoud - Regulatory peptides, 2008 - Elsevier
Food interacts with sensors all along the alimentary canal to provide the brain with
information regarding its composition, energy content, and beneficial effect. Vagal afferents …

Central Nesfatin-1 Reduces Dark-Phase Food Intake and Gastric Emptying in Rats: Differential Role of Corticotropin-Releasing Factor2 Receptor

A Stengel, M Goebel, L Wang, J Rivier, P Kobelt… - …, 2009 - academic.oup.com
Nesfatin-1, derived from nucleobindin2, is expressed in the hypothalamus and reported in
one study to reduce food intake (FI) in rats. To characterize the central anorexigenic action of …

The effects of oxytocin on appetite regulation, food intake and metabolism in humans

L Kerem, EA Lawson - International Journal of Molecular Sciences, 2021 - mdpi.com
The hypothalamic peptide oxytocin and its receptor are involved in a range of physiological
processes, including parturition, lactation, cell growth, wound healing, and social behavior …