[PDF][PDF] Age-related macular degeneration: epidemiology, pathophysiology, diagnosis, and treatment

H Vyawahare, P Shinde - Cureus, 2022 - cureus.com
The greatest global root of irremediable amaurosis in the venerable is age-related macular
degeneration (AMD), a complex eye condition. Clinically, AMD is characterized as being in …

A systematic review: Virtual-reality-based techniques for human exercises and health improvement

SG Ali, X Wang, P Li, Y Jung, L Bi, J Kim… - Frontiers in public …, 2023 - frontiersin.org
Virtual Reality (VR) has emerged as a new safe and efficient tool for the rehabilitation of
many childhood and adulthood illnesses. VR-based therapies have the potential to improve …

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction

Y Henning, US Blind, S Larafa, J Matschke… - Cell death & …, 2022 - nature.com
Oxidative stress and hypoxia in the retinal pigment epithelium (RPE) have long been
considered major risk factors in the pathophysiology of age-related macular degeneration …

Treatment avenues for age-related macular degeneration: Breakthroughs and bottlenecks

P Kumbhar, K Kolekar, S Vishwas, P Shetti… - Ageing Research …, 2024 - Elsevier
Age-related macular degeneration (AMD) is a significant factor contributing to serious vision
loss in adults above 50. The presence of posterior segment barriers serves as chief …

PolySialic acid-nanoparticles inhibit macrophage mediated inflammation through Siglec agonism: A potential treatment for age related macular degeneration

A Krishnan, VG Sendra, D Patel, A Lad… - Frontiers in …, 2023 - frontiersin.org
Age-related macular degeneration (AMD) is a chronic, progressive retinal disease
characterized by an inflammatory response mediated by activated macrophages and …

[HTML][HTML] Role of vitronectin and its receptors in neuronal function and neurodegenerative diseases

Y Ruzha, J Ni, Z Quan, H Li, H Qing - International Journal of Molecular …, 2022 - mdpi.com
Vitronectin (VTN), a multifunctional glycoprotein with various physiological functions, exists
in plasma and the extracellular matrix. It is known to be involved in the cell attachment …

Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degeneration

S Dehghan, R Mirshahi, A Shoae-Hassani… - Stem cell research & …, 2022 - Springer
Retinal pigment epithelium (RPE) degeneration is the hallmark of age-related macular
degeneration (AMD). AMD, as one of the most common causes of irreversible visual …

[HTML][HTML] Therapeutic approaches for age-related macular degeneration

RM Galindo-Camacho, C Blanco-Llamero… - International journal of …, 2022 - mdpi.com
Damage to the retinal pigment epithelium, Bruch's membrane and/or tissues underlying
macula is known to increase the risk of age-related macular degeneration (AMD). AMD is …

Vitreous humor proteome: unraveling the molecular mechanisms underlying proliferative and neovascular vitreoretinal diseases

FM Dos Santos, S Ciordia, J Mesquita… - Cellular and Molecular …, 2023 - Springer
Proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and
neovascular age-related macular degeneration (nAMD) are among the leading causes of …

Beyond VEGF: targeting inflammation and other pathways for treatment of retinal disease

A Muniyandi, GD Hartman, Y Song, M Mijit… - The Journal of …, 2023 - Elsevier
Neovascular eye diseases include conditions such as retinopathy of prematurity,
proliferative diabetic retinopathy, and neovascular age-related macular degeneration …