Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in
organisms ranging from slime molds to mammals. Central to their function is their ability to …

Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …

Neutrophils play a critical role in the host defense against bacterial and fungal infections, but
their inappropriate activation also contributes to tissue damage during autoimmune and …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

Alzheimer's disease (AD) remains one of the grand challenges facing human society. Much
controversy exists around the complex and multifaceted pathogenesis of this prevalent …

Neutrophils are essential effector cells of the innate immune response and are
indispensable for host defense. Apart from their antimicrobial functions, neutrophils inform …

Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …