Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …

Clostridioides difficile causes a range of debilitating intestinal symptoms that may be fatal. It
is particularly problematic as a hospital-acquired infection, causing significant costs to the …

The emergence of hypervirulent clade 2 Clostridioides difficile is associated with severe
symptoms and accounts for> 20% of global infections. TcdB is a dominant virulence factor of …

Hemorrhagic toxin (TcsH) is a major virulence factor produced by Paeniclostridium sordellii,
which is a non-negligible threat to women undergoing childbirth or abortions. Recently …

Snakebite envenoming is a significant global health challenge, and for over a century,
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …

Clostridioides difficile toxin B (TcdB) is the key virulence factor accounting for C. difficile
infection-associated symptoms. Effectively neutralizing different TcdB variants with a …

Clostridioides difficile toxins (TcdA and TcdB) are major exotoxins responsible for C. difficile
infection (CDI) associated diseases. The previously reported TcdB variants showed distinct …

We report the engineering and selection of two synthetic proteins—FSR16m and FSR22—
for the possible treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

The paradigm of antivirulence therapy dictates that bacterial pathogens are specifically
disarmed but not killed by neutralizing their virulence factors. Clearance of the invading …

Pathogenic clostridial species secrete potent toxins that induce severe host tissue damage.
Paeniclostridium sordellii lethal toxin (TcsL) causes an almost invariably lethal toxic shock …