Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation
In antibody responses, mutated germinal center B (BGC) cells are positively selected for
reentry or differentiation. As the products from GCs, memory B cells and antibody-secreting …
reentry or differentiation. As the products from GCs, memory B cells and antibody-secreting …
Protein purification strategies must consider downstream applications and individual biological characteristics
Background Proteins are used as reagents in a broad range of scientific fields. The reliability
and reproducibility of experimental data will largely depend on the quality of the …
and reproducibility of experimental data will largely depend on the quality of the …
[HTML][HTML] Recombinant N-terminal outer membrane porin (OprF) of Pseudomonas aeruginosa is a promising vaccine candidate against both P. aeruginosa and some …
Pseudomonas aeruginosa is an evolving pathogen which can cause serious infections
especially to immunocompromised patients. Its high resistance profile to antibiotics results in …
especially to immunocompromised patients. Its high resistance profile to antibiotics results in …
Immunization with the ferric iron-binding periplasmic protein HitA provides protection against Pseudomonas aeruginosa in the murine infection model
MA Elhosary, M Bahey-El-Din, A AbdelBary… - Microbial …, 2019 - Elsevier
Pseudomonas aeruginosa is a notorious pathogen with increasing multi-drug resistance.
This situation makes it urgent to develop a prophylactic vaccine against this pathogen …
This situation makes it urgent to develop a prophylactic vaccine against this pathogen …
High-level expression and efficient refolding of therapeutically important recombinant human Interleukin-3 (hIL-3) in E. coli
Abstract Human interleukin-3 (hIL-3) is a pleiotropic cytokine that stimulates the
differentiation and proliferation of multipotent hematopoietic cells thus making it a …
differentiation and proliferation of multipotent hematopoietic cells thus making it a …
A chemokine-fusion vaccine targeting immature dendritic cells elicits elevated antibody responses to malaria sporozoites in infant macaques
K Luo, JT Gordy, F Zavala, RB Markham - Scientific reports, 2021 - nature.com
Infants and young children are the groups at greatest risk for severe disease resulting from
Plasmodium falciparum infection. We previously demonstrated in mice that a protein vaccine …
Plasmodium falciparum infection. We previously demonstrated in mice that a protein vaccine …
Recombinant Ax21 protein is a promising subunit vaccine candidate against Stenotrophomonas maltophilia in a murine infection model
Stenotrophomonas maltophilia is an emerging pathogen that can cause several disease
manifestations such as bacteremia, meningitis, respiratory tract infections and others. More …
manifestations such as bacteremia, meningitis, respiratory tract infections and others. More …
Potent antitumor activity of a designed interleukin-21 mimic
Long-standing goals of cancer immunotherapy are to activate cytotoxic antitumor T cells
across a broad range of affinities while dampening suppressive regulatory T (Treg) cell …
across a broad range of affinities while dampening suppressive regulatory T (Treg) cell …
Extended protection capabilities of an immature dendritic-cell targeting malaria sporozoite vaccine
K Luo, F Zavala, J Gordy, H Zhang, RB Markham - Vaccine, 2017 - Elsevier
Mouse studies evaluating candidate malaria vaccines have typically examined protective
efficacy over the relatively short time frames of several weeks after the final of multiple …
efficacy over the relatively short time frames of several weeks after the final of multiple …
[HTML][HTML] Immunization with the basic membrane protein (BMP) family ABC transporter elicits protection against Enterococcus faecium in a murine infection model
Enterococcus faecium is evolving as a multi-resistant pathogen causing infections with high
morbidity and mortality. A protective vaccine against E. faecium is lacking up till now. ATP …
morbidity and mortality. A protective vaccine against E. faecium is lacking up till now. ATP …