MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and …
RM Zinkernagel, PC Doherty - Advances in immunology, 1979 - Elsevier
Publisher Summary This chapter focuses on the important discovery that virus-specific
cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by …
cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by …
Superantigens and their potential role in human disease
BL Kotzin, DYM Leung, J Kappler, P Marrack - Advances in immunology, 1993 - Elsevier
Publisher Summary This chapter provides evidence that indicates a potential role for
superantigens in the pathogenesis of several human diseases. The term “superantigen” was …
superantigens in the pathogenesis of several human diseases. The term “superantigen” was …
Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
Metazoan organisms may discriminate between self and non-self not only by the presence
of foreign antigens but also by the absence of normal self markers1. Mammalian adaptive …
of foreign antigens but also by the absence of normal self markers1. Mammalian adaptive …
Heterologous protection against influenza by injection of DNA encoding a viral protein
JB Ulmer, JJ Donnelly, SE Parker, GH Rhodes… - Science, 1993 - science.org
Cytotoxic T lymphocytes (CTLs) specific for conserved viral antigens can respond to different
strains of virus, in contrast to antibodies, which are generally strain-specific. The generation …
strains of virus, in contrast to antibodies, which are generally strain-specific. The generation …
Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.
MJ Bevan - The Journal of experimental medicine, 1976 - rupress.org
Cytotoxic effector T cells of F1 (BALB/c X BALB. B)(H-2d/b) mice immunized against the
minor histocompatibility differences of C57BL/10 (H-2b) can lyse targets from C57BL/10, but …
minor histocompatibility differences of C57BL/10 (H-2b) can lyse targets from C57BL/10, but …
Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice.
RM Steinman, MD Witmer - Proceedings of the National …, 1978 - National Acad Sciences
Dendrite cells (DCs) are a new cell type initially identified in mouse lymphoid organs.
Recently, DCs have been purified from mouse spleen. This paper demonstrates a functional …
Recently, DCs have been purified from mouse spleen. This paper demonstrates a functional …
Genetic basis for species vulnerability in the cheetah
A population genetic survey of over 200 structural loci previously revealed that the South
African cheetah (Acinonyx jubatus jubatus) has an extreme paucity of genetic variability …
African cheetah (Acinonyx jubatus jubatus) has an extreme paucity of genetic variability …
A biological role for the major histocompatibility antigens
PC Doherty, RM Zinkernagel - The Lancet, 1975 - Elsevier
A central function of the major histo-compatibility (H) antigens may be to signal changes in
self to the immune system. Virus-induced modification of strong transplantation antigens …
self to the immune system. Virus-induced modification of strong transplantation antigens …
Role of MHC gene products in immune regulation
B Benacerraf - Science, 1981 - science.org
1229 1), the random copolymers of L-glutamic acid and L-lysine (GL), L-glutamic acid and L-
alanine (GA), and L-glutamic acid and L-tyrosine (GT)(29). The response to conventional …
alanine (GA), and L-glutamic acid and L-tyrosine (GT)(29). The response to conventional …
Genes regulating HLA class I antigen expression in TB lymphoblast hybrids
RD Salter, DN Howell, P Cresswell - Immunogenetics, 1985 - Springer
Regulation of HLA class I and class II antigen expression was studied in hybrids of human T
and B lymphoblastoid cell lines (LCL). The T-LCL CEM R. 3 expresses no HLA class II …
and B lymphoblastoid cell lines (LCL). The T-LCL CEM R. 3 expresses no HLA class II …