Prediabetes is a state of elevated plasma glucose in which the threshold for diabetes has
not yet been reached and can predispose to the development of type 2 diabetes and …

Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central
regulator of redox, metabolic, and protein homeostasis that intersects with many other …

The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the
expression of antioxidant and detoxification genes. Gene knockout approaches have …

Cardiovascular diseases (CVDs) contribute to a large part of worldwide mortality. Similarly,
two of the major risk factors for these diseases, aging and obesity, are also global problems …

Over the last decade, hydrogen sulfide (H 2 S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

Although immunotherapy by PD-1 blockade has dramatically improved the survival rate of
cancer patients, further improvement in efficacy is required to reduce the fraction of less …

Key points Reactive oxygen species (ROS) and nitric oxide (NO) regulate exercise‐induced
nuclear factor erythroid 2‐related factor 2 (NFE2L2) expression in skeletal muscle. NFE2L2 …

Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this
disease remains a major source of morbidity and mortality worldwide, and prevalence …

Antigen-activated B cells diversify variable regions of B cell antigen receptors by somatic
hypermutation in germinal centers (GCs). The positive selection of GC B cells that acquire …