Regulation of microtubule dynamics, mechanics and function through the growing tip
Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …
The tubulin code and its role in controlling microtubule properties and functions
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, sha**, motility and intracellular transport. Despite their functional heterogeneity …
division, sha**, motility and intracellular transport. Despite their functional heterogeneity …
Structure of the native γ-tubulin ring complex cap** spindle microtubules
Microtubule (MT) filaments, composed of α/β-tubulin dimers, are fundamental to cellular
architecture, function and organismal development. They are nucleated from MT organizing …
architecture, function and organismal development. They are nucleated from MT organizing …
Microtubule dynamics: an interplay of biochemistry and mechanics
Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …
organization, organelle trafficking and chromosome segregation. Microtubule growth and …
Microtubule-targeting agents: strategies to hijack the cytoskeleton
Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …
the most important medical weapons available to combat cancer. MTAs interfere with …
A microtubule bestiary: structural diversity in tubulin polymers
Microtubules are long, slender polymers of αβ-tubulin found in all eukaryotic cells. Tubulins
associate longitudinally to form protofilaments, and adjacent protofilaments associate …
associate longitudinally to form protofilaments, and adjacent protofilaments associate …
Separating the effects of nucleotide and EB binding on microtubule structure
Microtubules (MTs) are polymers assembled from αβ-tubulin heterodimers that display the
hallmark behavior of dynamic instability. MT dynamics are driven by GTP hydrolysis within …
hallmark behavior of dynamic instability. MT dynamics are driven by GTP hydrolysis within …
Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins
In living cells, microtubules (MTs) play pleiotropic roles, which require very different
mechanical properties. Unlike the dynamic MTs found in the cytoplasm of metazoan cells …
mechanical properties. Unlike the dynamic MTs found in the cytoplasm of metazoan cells …
The structure and dynamics of C. elegans tubulin reveals the mechanistic basis of microtubule growth
The dynamic instability of microtubules is a conserved and fundamental mechanism in
eukaryotes. Yet microtubules from different species diverge in their growth rates, lattice …
eukaryotes. Yet microtubules from different species diverge in their growth rates, lattice …
Microtubules: From understanding their dynamics to using them as potential therapeutic targets
Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …