In the last decade, single-cell RNA sequencing routinely performed on large numbers of
single cells has greatly advanced our understanding of the underlying heterogeneity of …

Single-cell methodologies and technologies have started a revolution in biology which until
recently has primarily been limited to deep sequencing and imaging modalities. With the …

The recent technological and computational advances in mass spectrometry-based single-
cell proteomics have pushed the boundaries of sensitivity and throughput. However …

The analysis of ultralow input samples or even individual cells is essential to answering a
multitude of biomedical questions, but current proteomic workflows are limited in their …

We combined efficient sample preparation and ultra‐low‐flow liquid chromatography with a
newly developed data acquisition and analysis scheme termed wide window acquisition …

Mass spectrometry (MS) has emerged at the forefront of quantitative proteomic techniques.
Liquid chromatography‐mass spectrometry (LC‐MS) can be used to determine abundances …

Comprehensive proteomic analysis is essential to elucidate molecular pathways and protein
functions. Despite tremendous progress in proteomics, current studies still suffer from limited …

Proteins are intimately involved in executing and controlling virtually all cellular processes.
To understand the molecular mechanisms that underlie plant phenotypes, it is essential to …

The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

Single cell proteomics is a powerful tool with potential for markedly enhancing
understanding of cellular processes. Here we report the development and application of …