Choosing the right cell line for breast cancer research
DL Holliday, V Speirs - Breast cancer research, 2011 - Springer
Breast cancer is a complex and heterogeneous disease. Gene expression profiling has
contributed significantly to our understanding of this heterogeneity at a molecular level …
contributed significantly to our understanding of this heterogeneity at a molecular level …
The story of MCF-7 breast cancer cell line: 40 years of experience in research
Breast cancer is the most frequent malignancy in females. Due to its major impact on
population, this disease represents a critical public health problem that requires further …
population, this disease represents a critical public health problem that requires further …
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
cDNA microarrays and a clustering algorithm were used to identify patterns of gene
expression in human mammary epithelial cells growing in culture and in primary human …
expression in human mammary epithelial cells growing in culture and in primary human …
MCF-7 cells—changing the course of breast cancer research and care for 45 years
It is 45 years since a pleural effusion from a patient with metastatic breast cancer led to the
generation of the MCF-7 breast cancer cell line. MCF-7 is the most studied human breast …
generation of the MCF-7 breast cancer cell line. MCF-7 is the most studied human breast …
The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice
P Y. Maximov, T M. Lee… - Current clinical …, 2013 - benthamdirect.com
Selective estrogen receptor modulators (SERMs) are structurally different compounds that
interact with intracellular estrogen receptors in target organs as estrogen receptor agonists …
interact with intracellular estrogen receptors in target organs as estrogen receptor agonists …
Impairment of angiogenesis by fatty acid synthase inhibition involves mTOR malonylation
The role of fatty acid synthesis in endothelial cells (ECs) remains incompletely
characterized. We report that fatty acid synthase knockdown (FASN KD) in ECs impedes …
characterized. We report that fatty acid synthase knockdown (FASN KD) in ECs impedes …
Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis
Eupatorin has been reported with in vitro cytotoxic effect on several human cancer cells.
However, reports on the mode of action and detail mechanism of eupatorin in vitro in breast …
However, reports on the mode of action and detail mechanism of eupatorin in vitro in breast …
Canine mammary tumors as a model for human disease
SM Abdelmegeed, S Mohammed - Oncology letters, 2018 - spandidos-publications.com
Animal models for examining human breast cancer (HBC) carcinogenesis have been
extensively studied and proposed. With the recent advent of immunotherapy, significant …
extensively studied and proposed. With the recent advent of immunotherapy, significant …
A bone‐seeking clone exhibits different biological properties from the MDA‐MB‐231 parental human breast cancer cells and a brain‐seeking clone in vivo and in vitro
T Yoneda, PJ Williams, T Hiraga… - Journal of bone and …, 2001 - academic.oup.com
Breast cancer has a predilection for spreading to bone. The mechanism of preferential
metastasis of breast cancer to bone is unknown. We hypothesize that breast cancer cells …
metastasis of breast cancer to bone is unknown. We hypothesize that breast cancer cells …
Generation of multicellular breast cancer tumor spheroids: comparison of different protocols
K Froehlich, JD Haeger, J Heger, J Pastuschek… - Journal of mammary …, 2016 - Springer
Multicellular tumor spheroids are widely used models in tumor research. Because of their
three dimensional organization they can simulate avascular tumor areas comprising …
three dimensional organization they can simulate avascular tumor areas comprising …