Schizophrenia (SCZ) is a complex mental disorder characterized by a range of symptoms,
including positive and negative symptoms, as well as cognitive impairments. Despite the …

In vitro and preclinical in vivo research in the last 35 years has clearly highlighted the crucial
physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes and …

Maternal immune activation (MIA) during critical windows of gestation is correlated with long-
term neurodevelopmental deficits in the offspring, including increased risk for autism …

Abstract “Neurodegenerative disorder” is an umbrella term for a group of fatal progressive
neurological illnesses characterized by neuronal loss and inflammation. Interleukin-6 (IL-6) …

Background Depression in pregnancy can increase vulnerability for psychiatric disorders in
the offspring, likely via the transfer of heightened maternal cortisol and cytokines to the in …

Human endogenous retroviruses (HERVs) are repetitive elements previously implicated in
major psychiatric conditions, but their role in aetiology remains unclear. Here, we perform …

Prenatal infections and activation of the maternal immune system have been proposed to
contribute to causing neurodevelopmental disorders (NDDs), chronic conditions often linked …

Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed
to neural differentiation, termed “brain organoids” are now employed as an in vitro assay that …

Maternal immune activation (MIA) increases the risks for neurodevelopmental disorders in
offspring through inflammatory cytokines, including interleukin-6 (IL-6). We therefore aimed …

Autism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental conditions,
with a highly diverse genetic hereditary component, including altered neuronal circuits, that …