Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y ** single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …

Microfluidic impedance cytometry enabled one‐step sample preparation for efficient single‐cell mass spectrometry

J Zhu, S Pan, H Chai, P Zhao, Y Feng, Z Cheng… - Small, 2024 - Wiley Online Library
Single‐cell mass spectrometry (MS) is significant in biochemical analysis and holds great
potential in biomedical applications. Efficient sample preparation like sorting (ie, separating …

The neurovasculome: key roles in brain health and cognitive impairment: a scientific statement from the American Heart Association/American Stroke Association

C Iadecola, EE Smith, J Anrather, C Gu, A Mishra… - Stroke, 2023 - ahajournals.org
Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging

H Zhang, Y Liu, L Fields, X Shi, P Huang, H Lu… - Nature …, 2023 - nature.com
Single-cell (SC) analysis provides unique insight into individual cell dynamics and cell-to-
cell heterogeneity. Here, we utilize trapped ion mobility separation coupled with dual …

Omics approaches for the assessment of biological responses to nanoparticles

Y Abdelkader, L Perez-Davalos, R LeDuc… - Advanced Drug Delivery …, 2023 - Elsevier
Nanotechnology has enabled the development of innovative therapeutics, diagnostics, and
drug delivery systems. Nanoparticles (NPs) can influence gene expression, protein …

A guide to systems-level immunomics

L Bonaguro, J Schulte-Schrep**, T Ulas… - Nature …, 2022 - nature.com
The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …

[HTML][HTML] Single-cell metabolomics: where are we and where are we going?

I Lanekoff, VV Sharma, C Marques - Current opinion in biotechnology, 2022 - Elsevier
Single-cell metabolomics with mass spectrometry enables a large variety of metabolites to
be simultaneously detected from individual cells, without any preselection or labelling, to …

Single-cell mass spectrometry

M Tajik, M Baharfar, WA Donald - Trends in Biotechnology, 2022 - cell.com
Owing to recent advances in mass spectrometry (MS), tens to hundreds of proteins, lipids,
and small molecules can be measured in single cells. The ability to characterize the …