Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Heart failure (HF) is the most rapidly growing cardiovascular health burden worldwide. HF
can be classified into three groups based on the percentage of the ejection fraction (EF) …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Ventricular arrhythmias and contractile dysfunction are the main causes of death in human
heart failure (HF). In a rabbit HF model reproducing these same aspects of human HF, we …

Background—Ventricular pacing can improve hemodynamics in heart failure patients, but
direct effects on left ventricular (LV) function from varying pacing site and atrioventricular …

The sarcoendoplasmic reticulum (SR) calcium transport ATPase (SERCA) is a pump that
transports calcium ions from the cytoplasm into the SR. It is present in both animal and plant …

Background During the development of heart failure (HF), the chief myocardial energy
substrate switches from fatty acids to glucose. This metabolic switch, which recapitulates …

1. Introduction Administration Heart Failure Trial) and other trials suggest that death is
disproportionately sudden in patients with Over 2 million Americans suffer from heart failure …

Expression of sarcoplasmic reticulum (SR) Ca (2+)-ATPase was shown to be reduced in
failing human myocardium. The functional relevance of this finding, however, is not known …

Intracellular Ca2 is the central regulator of cardiac contrac-tility. Moreover, it is becoming
increasingly apparent that alterations in myocyte Ca2 regulation may be critically important …