The muscle extracellular matrix (ECM) forms a complex network of collagens, proteoglycans,
and other proteins that produce a favorable environment for muscle regeneration, protect the …

The world population is increasingly aging, deeply affecting our society by challenging our
healthcare systems and presenting an economic burden, thus turning the spotlight on aging …

Abstract Advanced-Glycation-Endproducts (AGEs) are known to be a major cause of
impaired tissue material properties. In collagen fibrils, which constitute a major building …

Large bone defect regeneration remains a major challenge for orthopedic surgeons. Tissue
engineering approaches are therefore emerging in order to overcome this limitation …

The mineralized collagen fibril is the main building block of hard tissues and it directly affects
the macroscopic mechanics of biological tissues such as bone. The mechanical behavior of …

Fracture risk in type 2 diabetes (T2D) patients is paradoxically increased despite no
decrease in areal bone mineral density (BMD). This phenomenon, known as the “diabetic …

Skin undergoes mechanical alterations due to changes in the composition and structure of
the collagenous dermis with aging. Previous studies have conflicting findings, with both …

During aging, muscles undergo atrophy, which is partly accounted for by a loss of
sarcomeres in series. Serial sarcomere number (SSN) is associated with aspects of muscle …

Various studies have correlated the mechanical properties of the aortic wall with its
biochemical parameters and inner structure. Very few studies have addressed correlations …

The consensus in aging is that inflammation, cellular senescence, free radicals, and
epigenetics are contributing factors. Skin glycation through advanced glycation end products …