Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2024 - journals.physiology.org
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Computational techniques for ECG analysis and interpretation in light of their contribution to medical advances

A Lyon, A Mincholé, JP Martínez… - Journal of The …, 2018 - royalsocietypublishing.org
Widely developed for clinical screening, electrocardiogram (ECG) recordings capture the
cardiac electrical activity from the body surface. ECG analysis can therefore be a crucial first …

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

R Piersanti, PC Africa, M Fedele, C Vergara… - Computer Methods in …, 2021 - Elsevier
Since myocardial fibers drive the electric signal propagation throughout the myocardium,
accurately modeling their arrangement is essential for simulating heart electrophysiology …

Computational models of atrial fibrillation: Achievements, challenges, and perspectives for improving clinical care

J Heijman, H Sutanto, HJGM Crijns… - Cardiovascular …, 2021 - academic.oup.com
Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …

Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity

FH Fenton, EM Cherry, HM Hastings… - … Journal of Nonlinear …, 2002 - pubs.aip.org
It has become widely accepted that the most dangerous cardiac arrhythmias are due to
reentrant waves, ie, electrical wave (s) that recirculate repeatedly throughout the tissue at a …

Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation

SV Pandit, O Berenfeld, JMB Anumonwo, RM Zaritski… - Biophysical journal, 2005 - cell.com
Recent studies suggest that atrial fibrillation (AF) is maintained by fibrillatory conduction
emanating from a small number of high-frequency reentrant sources (rotors). Our goal was …

Computational techniques for solving the bidomain equations in three dimensions

EJ Vigmond, F Aguel… - IEEE Transactions on …, 2002 - ieeexplore.ieee.org
The bidomain equations are the most complete description of cardiac electrical activity. Their
numerical solution is, however, computationally demanding, especially in three dimensions …

Computational modeling of the human atrial anatomy and electrophysiology

O Dössel, MW Krueger, FM Weber, M Wilhelms… - Medical & biological …, 2012 - Springer
This review article gives a comprehensive survey of the progress made in computational
modeling of the human atria during the last 10 years. Modeling the anatomy has emerged …

From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales

G Plank, L Zhou, JL Greenstein… - … of the Royal …, 2008 - royalsocietypublishing.org
Computer simulations of electrical behaviour in the whole ventricles have become
commonplace during the last few years. The goals of this article are (i) to review the …