Synonymous mutations—sometimes called'silent'mutations—are now widely acknowledged
to be able to cause changes in protein expression, conformation and function. The recent …

Recent advances in next-generation sequencing (NGS) and single nucleotide
polymorphism (SNP) genoty** promise to greatly accelerate crop improvement if properly …

There is increasing evidence that genome-wide association (GWA) studies represent a
powerful approach to the identification of genes involved in common human diseases. We …

Whole-genome association studies present many new statistical and computational
challenges due to the large quantity of data obtained. One of these challenges is haplotype …

Inherited genetic variation has a critical but as yet largely uncharacterized role in human
disease. Here we report a public database of common variation in the human genome: more …

Chromosomal aberrations are a hallmark of acute lymphoblastic leukaemia (ALL) but alone
fail to induce leukaemia. To identify cooperating oncogenic lesions, we performed a genome …

R estriction site a ssociated D NA (RAD) tags are a genome-wide representation of every
site of a particular restriction enzyme by short DNA tags. Most organisms segregate large …

Neuroblastoma in advanced stages is one of the most intractable paediatric cancers, even
with recent therapeutic advances. Neuroblastoma harbours a variety of genetic changes …

The Rembrandt brain cancer dataset includes 671 patients collected from 14 contributing
institutions from 2004–2006. It is accessible for conducting clinical translational research …