Osteolytic bone disease is the hallmark of multiple myeloma, which deteriorates the quality
of life of myeloma patients, and it affects dramatically their morbidity and mortality. The basis …

Osteoporosis is a skeletal disorder characterized by decreased mass and compromised
bone strength predisposing to an increased risk of fractures. Although idiopathic …

Background Multiple myeloma is characterised by monoclonal paraprotein production and
osteolytic lesions, commonly leading to skeletal-related events (spinal cord compression …

Bone metastasis is a major cause of morbidity in persons with cancer. Complications include
pain, impaired mobility, pathological fracture, spinal cord compression, cranial nerve …

Background Myeloma cells may secrete factors that affect the function of osteoblasts,
osteoclasts, or both. Methods We subjected purified plasma cells from the bone marrow of …

All osteogenic cells (osteoclasts, osteoblasts) contribute individually to bone remodeling.
Their cellular interactions control their cellular activities and the bone remodeling intensity …

Osteoclasts and osteoblasts dictate skeletal mass, structure, and strength via their respective
roles in resorbing and forming bone. Bone remodeling is a spatially coordinated lifelong …

Bone resorption by osteoclasts is coupled with bone formation by osteoblasts, and this
balanced process continuously remodels and adapts the skeleton. The receptor activator of …

The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …

The skeleton and the immune system share a variety of different cytokines and transcription
factors, thereby mutually influencing each other. These interactions are not confined to the …