Diabetes-Alzheimer's connection in older age: SGLT2 inhibitors as promising modulators of disease pathways

F Mancinetti, D Xenos, M De Fano, A Mazzieri… - Ageing Research …, 2023 - Elsevier
Late-onset Alzheimer's disease (LOAD) is the most frequent cause of dementia in older
persons. Subjects affected by type 2 diabetes mellitus (T2DM) are at higher risk of vascular …

[HTML][HTML] The Intersection between Frailty, Diabetes, and Hypertension: The Critical Role of Community Geriatricians and Pharmacists in Deprescribing

D Dinarvand, J Panthakey, A Heidari, A Hassan… - Journal of Personalized …, 2024 - mdpi.com
Background: Frailty is a clinical syndrome prevalent among the elderly, characterised by a
decline in physiological reserves and increased susceptibility to stressors, resulting in …

Glucose transport and utilization in the hippocampus: from neurophysiology to diabetes-related development of dementia

CY Yonamine, MLE Michalani, RJ Moreira… - International journal of …, 2023 - mdpi.com
The association of diabetes with cognitive dysfunction has at least 60 years of history, which
started with the observation that children with type 1 diabetes mellitus (T1D), who had …

Cognitive disorders in type 1 diabetes: Role of brain glucose variation, insulin activity and glucocorticoid exposure

J Brossaud, P Barat, MP Moisan - Neuroendocrinology, 2024 - karger.com
Background: The number of patients with type 2 diabetes (T2D) and type 1 diabetes (T1D) is
on the rise, partly due to a global increase in new T1D cases among children. Beyond the …

The crosstalk of different mechanisms in cognitive impairment associated with aging, Alzheimer's disease, and related dementias

L Giménez-Llort - Frontiers in aging neuroscience, 2023 - frontiersin.org
In recent years, significant advances have been made in understanding the pathogenesis
and treatment of Alzheimer's disease (AD). Growing evidence indicates that AD is a …

[HTML][HTML] Alterations in Brain Morphometric Networks and Their Relationship with Memory Dysfunction in Patients with Type 2 Diabetes Mellitus

RY Kim, Y Joo, E Ha, H Hong, C Suh… - Experimental …, 2024 - ncbi.nlm.nih.gov
Cognitive dysfunction, a significant complication of type 2 diabetes mellitus (T2DM), can
potentially manifest even from the early stages of the disease. Despite evidence of global …

Continuous Glucose Monitoring in Comorbid Dementia and Diabetes: The Evidence So Far

B Donat Ergin, K Gadsby-Davis… - Journal of Diabetes …, 2024 - journals.sagepub.com
Background: Type 2 diabetes mellitus (T2DM) and dementia are two of the leading chronic
diseases in aging and are known to influence each other's disease progression. There is …

Effects of prediabetes and type 2 diabetes on cognitive functions

GA Şen, S Tanrıkulu, B Beşer, Ş Akçakalem, S Çakır… - Endocrine, 2024 - Springer
Introduction We aimed to investigate the effect of glycemic impairment in prediabetes on
cognitive impairment and the impact of glycemic control on cognitive function in patients with …

[HTML][HTML] Postprandial hypoglycemia as a complication of bariatric and metabolic surgery: a comprehensive review of literature

M Karimi, OK Gargari - Frontiers in Surgery, 2024 - pmc.ncbi.nlm.nih.gov
Postprandial hypoglycemia (PPH) is a challenging and significant complication that can
occur following bariatric and metabolic surgery. Symptoms of PPH are typical of …

Unlocking hypoglycemia–associated brain microvascular dysfunction: critical insights from proteomic analysis

SSVP Sakamuri, A Sakamuri - Neural Regeneration Research, 2025 - journals.lww.com
Hypoglycemia is characterized by a decline in circulatory glucose levels below standard
physiological thresholds. Mild hypoglycemia, classified as level 1 hypoglycemia, is defined …