With increasing life expectancies and the desire to maintain active lifestyles well into old
age, the impact of the debilitating disease osteoarthritis (OA) and its burden on healthcare …

Early in the process of osteoarthritis (OA) the composition (water, proteoglycan [PG], and
collagen) and structure of articular cartilage is altered leading to changes in its mechanical …

Abstract Changes in the composition of the extracellular matrix (ECM) are characteristic of
injury or disease in cartilage tissue. Various imaging modalities and biochemical techniques …

Noninvasive assessment of engineered cartilage properties would enable better control of
the develo** tissue towards the desired structural and compositional endpoints through …

It is known that in the early stages of osteoarthritis, the concentration of glycan proteins
decreases in articular cartilage. This phenomenon is under active research to develop a …

Several laboratory and rotating frame quantitative MRI parameters were evaluated and
compared for detection of changes in articular cartilage following selective enzymatic …

Objective The purpose of this study is to evaluate the ability of machine learning to
discriminate between magnetic resonance images (MRI) of normal and pathological human …

Background Machine learning models trained with multiparametric quantitative MRIs
(qMRIs) have the potential to provide valuable information about the structural composition …

Objective To evaluate the usefulness of quantitative parameters obtained by optical
coherence tomography (OCT) and magnetic resonance imaging (MRI) in the comprehensive …

Association of MR parameters with cartilage matrix components remains an area of ongoing
investigation. Multiexponential analysis of nonlocalized transverse relaxation data has …