The dynamic interactions of cancer cells with their microenvironment consisting of stromal
cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to …

Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

We review the morphofunctional characteristics of pericytes and report our observations.
After a brief historical background, we consider the following aspects of pericytes: A) Origin …

Simple Summary Tumors are not masses of cancer cells alone but made up of cancer cells,
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …

Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …

Regeneration and tissue repair processes consist of a sequence of molecular and cellular
events which occur after the onset of a tissue lesion in order to restore the damaged tissue …

Activation of the tumor and stromal cell-driven angiogenic program is one of the first
requirements in the tumor ecosystem for growth and dissemination. The understanding of …

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and
progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly …

Tumours require a vascular supply to grow and can achieve this via the expression of pro-
angiogenic growth factors, including members of the vascular endothelial growth factor …