Diet, serving as a vital source of nutrients, exerts a profound influence on human health and
disease progression. Recently, dietary interventions have emerged as promising adjunctive …

The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central
role in regulating immune responses provided a deeper understanding of self-tolerance …

There is strong evidence for a causal relationship between salt intake and blood pressure.
Randomized trials demonstrate that salt reduction lowers blood pressure in both individuals …

Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs
have a long record of accomplishment as effective treatments for a wide range of diseases …

Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …

Choices have consequences. Immune cells survey and migrate throughout the body and
sometimes take residence in niche environments with distinct communities of cells …

CD8+ T cells control tumors but inevitably become dysfunctional in the tumor
microenvironment. Here, we show that sodium chloride (NaCl) counteracts T cell dysfunction …

Enthusiasm exists for the potential of diet to impact the immune system, prevent disease and
its therapeutic potential. Herein, we describe the challenge to nutrition scientists in defining …

The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS)
lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes …