Molecular complexities underlying the vascular complications of diabetes mellitus–A comprehensive review

S Paul, A Ali, R Katare - Journal of Diabetes and its Complications, 2020 - Elsevier
Diabetes is a chronic disease, characterized by hyperglycemia, which refers to the elevated
levels of glucose in the blood, due to the inability of the body to produce or use insulin …

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

KM Yap, M Sekar, LJ Seow, SH Gan… - … Cancer: Targets and …, 2021 - Taylor & Francis
Globally, breast cancer is the most common cancer type and is one of the most significant
causes of deaths in women. To date, multiple clinical interventions have been applied …

miRNA signatures associate with pathogenesis and progression of osteosarcoma

KB Jones, Z Salah, S Del Mare, M Galasso… - Cancer …, 2012 - aacrjournals.org
Osteosarcoma remains a leading cause of cancer death in adolescents. Treatment
paradigms and survival rates have not improved in two decades. Driving the lack of …

Influence of miRNA in insulin signaling pathway and insulin resistance: micro‐molecules with a major role in type‐2 diabetes

C Chakraborty, CGP Doss… - Wiley …, 2014 - Wiley Online Library
The prevalence of type‐2 diabetes (T2D) is increasing significantly throughout the globe
since the last decade. This heterogeneous and multifactorial disease, also known as insulin …

[HTML][HTML] Genetic and epigenetic modulations in toxicity: the two-sided roles of heavy metals and polycyclic aromatic hydrocarbons from the environment

PI Adegbola, A Adetutu - Toxicology Reports, 2024 - Elsevier
This study emphasizes the importance of considering the metabolic and toxicity mechanisms
of environmental concern chemicals in real-life exposure scenarios. Furthermore …

Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis

Z Deng, Y Rong, Y Teng, X Zhuang, A Samykutty, J Mu… - Oncogene, 2017 - nature.com
Acquired resistance to chemotherapy remains a major stumbling block in cancer treatment.
Chronic inflammation has a crucial role in induction of chemoresistance and results, in part …

Modulation of the osteosarcoma expression phenotype by microRNAs

HM Namløs, LA Meza-Zepeda, T Barøy, IHG Østensen… - PloS one, 2012 - journals.plos.org
Background Osteosarcomas are the most common primary malignant tumors of bone and
show multiple and complex genomic aberrations. miRNAs are non-coding RNAs capable of …

MicroRNA-126-3p/-5p overexpression attenuates blood-brain barrier disruption in a mouse model of middle cerebral artery occlusion

J Pan, M Qu, Y Li, L Wang, L Zhang, Y Wang, Y Tang… - Stroke, 2020 - ahajournals.org
Background and Purpose—Blood-brain barrier (BBB) disruption is a critical pathological
feature after stroke. MicroRNA-126 (miR-126) maintains BBB integrity by regulating …

MicroRNAs linking inflamm-aging, cellular senescence and cancer

F Olivieri, MR Rippo, V Monsurrò, S Salvioli… - Ageing research …, 2013 - Elsevier
Epidemiological and experimental data demonstrate a strong correlation between age-
related chronic inflammation (inflamm-aging) and cancer development. However, a …

miR-126 in human cancers: clinical roles and current perspectives

F Ebrahimi, V Gopalan, RA Smith, AKY Lam - Experimental and Molecular …, 2014 - Elsevier
Abstract miR-126 has been implicated in the processes of inflammation and angiogenesis.
Through these processes, miR-126 is implicated in cancer biology, but its role there has not …