Matrine: a promising natural product with various pharmacological activities

H Zhang, L Chen, X Sun, Q Yang, L Wan… - Frontiers in …, 2020 - frontiersin.org
Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens
Aiton. At present, a large number of studies have proved that matrine has an anticancer …

Matrine: A review of its pharmacology, pharmacokinetics, toxicity, clinical application and preparation researches

X Li, Z Tang, L Wen, C Jiang, Q Feng - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance “Dogel ebs” was known as Sophora flavescens Ait., which
has been widely utilized in the clinical practice of traditional Chinese Mongolian herbal …

Natural drugs as a treatment strategy for cardiovascular disease through the regulation of oxidative stress

X Chang, T Zhang, W Zhang, Z Zhao… - Oxidative Medicine and …, 2020 - Wiley Online Library
Oxidative stress (OS) refers to the physiological imbalance between oxidative and
antioxidative processes leading to increased oxidation, which then results in the …

Matrine alleviates cisplatin‐induced acute kidney injury by inhibiting mitochondrial dysfunction and inflammation via SIRT3/OPA1 pathway

L Yuan, J Yang, Y Li, L Yuan, F Liu… - Journal of Cellular …, 2022 - Wiley Online Library
Cisplatin is extensively used to treat malignancies. However, its clinical use is always limited
due to the serious side effects, especially the nephrotoxicity. Matrine (MAT), a tetracyclic …

[HTML][HTML] Curcumin protects against Aflatoxin B1-induced liver injury in broilers via the modulation of long non-coding RNA expression

S Li, R Liu, G Wei, G Guo, H Yu, Y Zhang… - Ecotoxicology and …, 2021 - Elsevier
Abstract Aflatoxin B1 (AFB1) is a potent hepatotoxic and carcinogenic agent. Curcumin
possesses potential anti-inflammatory, anti-oxidative and hepatoprotective effects. However …

Preparation, characterization, and pharmacological application of oral Honokiol-loaded solid lipid nanoparticles for diabetic neuropathy

T Bibi, S Bano, F ud Din, H Ali, S Khan - International Journal of …, 2023 - Elsevier
Honokiol is a phytochemical component with a variety of pharmacological properties.
However, the major limitation of Honokiol is its poor solubility and low oral bioavailability. In …

[HTML][HTML] Phytotherapeutic applications of alkaloids in treating breast cancer

S Rampogu, T Balasubramaniyam, JH Lee - Biomedicine & …, 2022 - Elsevier
Breast cancer is one of the major causes of mortality in women worldwide. The current
treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET) …

Quality by design for sumatriptan loaded nano-ethosomal mucoadhesive gel for the therapeutic management of nitroglycerin induced migraine

U Shafique, F ud Din, S Sohail, S Batool… - International Journal of …, 2023 - Elsevier
Migraine is a progressive neurological condition often accompanied by nausea and
vomiting. Various drugs have recently been used in the treatment of migraine, including …

An update of palmitoylethanolamide and luteolin effects in preclinical and clinical studies of neuroinflammatory events

M Cordaro, S Cuzzocrea, R Crupi - Antioxidants, 2020 - mdpi.com
The inflammation process represents of a dynamic series of phenomena that manifest
themselves with an intense vascular reaction. Neuroinflammation is a reply from the central …

[HTML][HTML] Suppression of TRPV1/TRPM8/P2Y nociceptors by withametelin via downregulating MAPK signaling in mouse model of vincristine-induced neuropathic pain

A Khan, B Shal, AU Khan, R Ullah, MW Baig… - International journal of …, 2021 - mdpi.com
Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …