Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
Regulation of cardiac hypertrophy by intracellular signalling pathways
The mammalian heart is a dynamic organ that can grow and change to accommodate
alterations in its workload. During development and in response to physiological stimuli or …
alterations in its workload. During development and in response to physiological stimuli or …
lncExACT1 and DCHS2 regulate physiological and pathological cardiac growth
Background: The heart grows in response to pathological and physiological stimuli. The
former often precedes cardiomyocyte loss and heart failure; the latter paradoxically protects …
former often precedes cardiomyocyte loss and heart failure; the latter paradoxically protects …
[كتاب][B] Excitation-contraction coupling and cardiac contractile force
D Bers - 2001 - books.google.com
How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …
What are the links between cardiac structure and function? How does our understanding of …
Cardiac hypertrophy: the good, the bad, and the ugly
▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …
[HTML][HTML] NFAT signaling: choreographing the social lives of cells
Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc
proteins into the nucleus, where they cooperate with other proteins to form complexes on …
proteins into the nucleus, where they cooperate with other proteins to form complexes on …
Hypertrophy of the heart: a new therapeutic target?
Recent studies call into question the necessity of hypertrophic growth of the heart as a
“compensatory” response to hemodynamic stress. These findings, coupled with recent …
“compensatory” response to hemodynamic stress. These findings, coupled with recent …
Calcium signaling and transcriptional regulation in cardiomyocytes
M Dewenter, A von der Lieth, HA Katus… - Circulation …, 2017 - Am Heart Assoc
Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …
Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy
Background—A variety of studies carried out using either human subjects or laboratory
animals suggest that vitamin D and its analogues possess important beneficial activity in the …
animals suggest that vitamin D and its analogues possess important beneficial activity in the …
[HTML][HTML] TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
The heart responds to injury and chronic pressure overload by pathologic growth and
remodeling, which frequently result in heart failure and sudden death. Calcium-dependent …
remodeling, which frequently result in heart failure and sudden death. Calcium-dependent …