Background: Gap junctions are clusters of intercellular channels allowing the bidirectional
pass of ions directly into the cytoplasm of adjacent cells. Electrical coupling mediated by gap …

Enhanced gap junctional communication (GJC) between neurons is considered a major
factor underlying the neuronal synchrony driving seizure activity. In addition, the …

Temporal lobe epilepsy (TLE) is one of the most common types of focal epilepsy,
characterized by recurrent spontaneous seizures originating in the temporal lobe (s), with …

The central nervous system (CNS) is composed of a highly heterogeneous population of
cells. Dynamic interactions between different compartments (neuronal, glial, and vascular …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …

In epilepsy research, emphasis is put on exploring non-neuronal targets such as astrocytic
proteins, since many patients remain pharmacoresistant to current treatments, which almost …

Gap junctions (GJs) are multiple cellular intercellular connections that allow ions to pass
directly into the cytoplasm of neighboring cells. Electrical coupling mediated by GJs plays a …

The blood-brain barrier (BBB) is a barrier system separating the central nervous system from
blood circulation. Connections between cells within the BBB involve specialized endothelial …

Epilepsy is a common neurological disorder characterized by periodic and unpredictable
seizures. Gap junctions have recently been proposed to be involved in the generation …

Chronic pain, including inflammatory, neuropathic pain, is a serious clinical issue. There are
increasing numbers of patients with chronic pain due to the growing number of elderly and it …