Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-
inflammatory effects, drugs that neutralize TNF were developed and are clinically used to …

Cellular responses to TNF are inherently heterogeneous within an isogenic cell population
and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF …

An important function of intestinal epithelial cells (IECs) is to maintain the integrity of the
mucosal barrier. Inflammation challenges the integrity of the mucosal barrier and the …

Newly discovered anti-cancer immunotherapies, such as immune checkpoint inhibitors and
chimeric antigen receptor T cells, focus on spurring the anti-tumor effector T cell (Teff) …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease, and Gegen Qinlian
Decoction (GQD), a Chinese botanical formula, has exhibited beneficial efficacy against UC …

Liver and muscle health are intimately connected. Nutritional strategies that support liver
detoxification are beneficial to muscle recovery. Computational–in silico–molecular systems' …

Isogenic cells sensing identical external signals can take markedly different decisions. Such
decisions often correlate with pre-existing cell-to-cell differences in protein levels. When not …

Cells in a genetically homogeneous cell‐population exhibit a significant degree of
heterogeneity in their responses to an external stimulus. To understand origins and …

The last decade has seen a rapid development of experimental techniques that allow data
collection from individual cells. These techniques have enabled the discovery and …

One of the most common observations in cell death assays is that not all cells die at the
same time, or at the same treatment dose. Here, using the perspective of the systems …