The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …

There is extensive evidence that aging is associated with impairments in episodic memory.
Many of these changes have been ascribed to neurobiological alterations to the …

This study examined the combined effect of physical exercise and cognitive training on
memory and neurotrophic factors in healthy, young adults. Ninety-five participants …

The human hippocampus supports the formation of episodic memory without confusing new
memories with old ones. To accomplish this, the brain must disambiguate memories (ie …

The dentate gyrus (DG) is crucial for behaviorally discriminating similar spatial memories,
predicting that DG place cells change (" remap") their relative spatial tuning (" place fields") …

Environmental manipulations can enhance neuroplasticity in the brain, with enrichment‐
induced cognitive improvements being linked to increased expression of growth factors …

Pattern separation is a process that minimizes overlap between patterns of neuronal activity
representing similar experiences. Theoretical work suggests that the dentate gyrus (DG) …

The hippocampus plays a key role in pattern separation, the process of transforming similar
incoming information to highly dissimilar, nonverlap** representations. Sparse firing …

Spatial memory deficits have been well-documented in older adults and may serve as an
early indicator of mild cognitive impairment (MCI) or Alzheimer's disease (AD) in some …

As a major component of the hippocampal trisynaptic circuit, the dentate gyrus (DG) relays
inputs from the entorhinal cortex to the CA3 subregion. Although the anatomy of the DG is …