The Hippo pathway: organ size control and beyond
The Hippo signaling pathway is a highly conserved signaling network for controlling organ
size, tissue homeostasis, and regeneration. It integrates a wide range of intracellular and …
size, tissue homeostasis, and regeneration. It integrates a wide range of intracellular and …
[HTML][HTML] The Hippo signaling pathway in gastric cancer: Targeting Hippo for GC treatment
Z Cao, L An, Y Han, S Jiao, Z Zhou - Acta Biochimica et Biophysica …, 2023 - ncbi.nlm.nih.gov
Gastric cancer (GC) is an aggressive malignant disease which still lacks effective early
diagnosis markers and targeted therapies, representing the fourth-leading cause of cancer …
diagnosis markers and targeted therapies, representing the fourth-leading cause of cancer …
Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP
Phosphoinositides are essential signaling molecules. The PI5P4K family of
phosphoinositide kinases and their substrates and products, PI5P and PI4, 5P2 …
phosphoinositide kinases and their substrates and products, PI5P and PI4, 5P2 …
PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation
Despite recent studies implicating liquid-like biomolecular condensates in diverse cellular
processes, many biomolecular condensates exist in a solid-like state, and their function and …
processes, many biomolecular condensates exist in a solid-like state, and their function and …
Crystal structure of the ORP8 lipid transport ORD domain: model of lipid transport
A Eisenreichova, M Klima, MM Anila, A Koukalova… - Cells, 2023 - mdpi.com
ORPs are lipid-transport proteins belonging to the oxysterol-binding protein family. They
facilitate the transfer of lipids between different intracellular membranes, such as the ER and …
facilitate the transfer of lipids between different intracellular membranes, such as the ER and …
Mammalian START-like phosphatidylinositol transfer proteins–Physiological perspectives and roles in cancer biology
PtdIns and its phosphorylated derivatives, the phosphoinositides, are the biochemical
components of a major pathway of intracellular signaling in all eukaryotic cells. These lipids …
components of a major pathway of intracellular signaling in all eukaryotic cells. These lipids …
Lipid transfer proteins and a PI 4-kinase initiate nuclear phosphoinositide signaling
Phosphoinositide (PIPn) messengers are present in non-membranous regions of nuclei,
where they are assembled into a phosphatidylinositol (PI) 3-kinase (PI3K)/Akt pathway that …
where they are assembled into a phosphatidylinositol (PI) 3-kinase (PI3K)/Akt pathway that …
[HTML][HTML] The expanding roles of PI4P and PI (4, 5) P2 at the plasma membrane: Role of phosphatidylinositol transfer proteins
S Cockcroft - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2024 - Elsevier
Phosphoinositides are phosphorylated derivatives of phosphatidylinositol, a phospholipid
that is synthesised at the endoplasmic reticulum. The plasma membrane contains the …
that is synthesised at the endoplasmic reticulum. The plasma membrane contains the …
Deciphering the change pattern of lipid metabolism in Saccharomyces cerevisiae responding to low temperature
C Yang, A Dong, L Deng, F Wang, J Liu - Biochemical Engineering Journal, 2023 - Elsevier
In fermentation, the yield of some lipid products is deeply affected by thermal variation.
However, changes in lipid metabolism responding to low temperature are still poorly …
However, changes in lipid metabolism responding to low temperature are still poorly …
Non-vesicular phosphatidylinositol transfer plays critical roles in defining organelle lipid composition
YJ Kim, JG Pemberton, A Eisenreichova… - The EMBO …, 2024 - embopress.org
Phosphatidylinositol (PI) is the precursor lipid for the minor phosphoinositides (PPIns), which
are critical for multiple functions in all eukaryotic cells. It is poorly understood how …
are critical for multiple functions in all eukaryotic cells. It is poorly understood how …