Although loss of TAR DNA-binding protein 43 kDa (TDP-43) splicing repression is well
documented in postmortem tissues of amyotrophic lateral sclerosis (ALS) and frontotemporal …

Neurological disorders are the leading cause of cognitive and physical disability worldwide,
affecting 15% of the global population. Due to the demographics of aging, the prevalence of …

Abstract TAR DNA binding protein-43 (TDP-43) is a key component in RNA splicing which
plays a crucial role in the aging process. In neurodegenerative diseases such as …

Nuclear clearance and cytoplasmic accumulations of the RNA-binding protein TDP-43 are
pathological hallmarks in almost all patients with amyotrophic lateral sclerosis (ALS) and up …

Abstract Background Inclusions of TAR DNA-binding protein 43 kDa (TDP-43) has been
designated limbic-predominant, age-related TDP-43 encephalopathy (LATE), with or without …

We have recently identified the aberrant nuclear accumulation of the ESCRT-III protein
CHMP7 as an initiating event that leads to a significant injury to the nuclear pore complex …

Genetic variation at the transmembrane protein 106B gene (TMEM106B) has been linked to
risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) through an …

A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic
hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal …

TDP-43 protein is dysregulated in several neurodegenerative diseases, which often have a
multifactorial nature and may have extrinsic stressors as a" second hit." TDP-43 undergoes …

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases |
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