Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

Nitric oxide (radical dot NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO
synthase isoforms, iNOS, eNOS and nNOS. The synthesis of NO is selectively inhibited by …

Increased vascular production of reactive oxygen species (ROS; termed oxidative stress)
has been implicated in various chronic diseases, including hypertension. Oxidative stress is …

Background Serum concentrations of symmetric dimethylarginine (SDMA) detected chronic
kidney disease (CKD) in cats an average of 17.0 months before serum creatinine (Cr) …

Hypertension is a leading risk factor for stroke, heart disease and chronic kidney disease.
Multiple interacting factors and organ systems increase blood pressure and cause target …

Background Symmetric dimethylarginine (SDMA) is an accurate and precise biomarker for
estimating glomerular filtration rate (GFR) in humans and cats. Serum creatinine (sC r) also …

Many factors have been implicated in the pathophysiology of hypertension such as
upregulation of the renin-angiotensin-aldosterone system, activation of the sympathetic …

The metabolic syndrome affects 30% of the US population with increasing prevalence. In
this paper, we explore the relationship between the metabolic syndrome and the incidence …

Asymmetric (NG, NG) dimethylarginine (ADMA) is present in plasma and cells. It can inhibit
nitric oxide synthase (NOS) that generates nitric oxide (NO) and cationic amino acid …

Hypertension reigns as a leading cause of cardiovascular morbidity and mortality worldwide.
Excessive reactive oxygen species (ROS) have emerged as a central common pathway by …