Our awareness and appreciation of the many regulatory roles of RNA have dramatically
increased in the past decade. This understanding, in addition to the impact of RNA in many …

The most popular RNA secondary structure prediction programs utilize free energy (Δ G° 37)
minimization and rely upon thermodynamic parameters from the nearest neighbor (NN) …

Although chemically close to DNA, RNA can adopt a wide range of structures from regular
helices to complex globular conformations, showing a complexity similar to that of proteins …

Transfer RNA (tRNA) is the most diversely modified RNA. Although the strictly conserved
purine position 37 in the anticodon stem–loop undergoes modifications that are …

The 2-methylthio-modification (ms2-) of N6-threonylcarbonyladenosine (t6A37) at position-
37 (ms2t6A37) in tRNAUUULys3 provides the needed stability between the tRNA anticodon …

Ribonucleotide: protein interactions play crucial roles in a number of biological processes.
Unlike the RNA: protein interface where van der Waals contacts are prevalent, the …

Post-transcriptionally modified bases play vital roles in many biochemical processes
involving RNA. Analysis of the non-covalent interactions associated with these bases in …

DFT calculations are employed to quantify the influence of the presence, number, nature,
and position of posttranscriptional methylation on stacking strength of RNA bases. We carry …

Hydrogen bonding between amino acids and nucleobases is important for RNA–protein
recognition. As a first step toward understanding the physicochemical features of these …

Abstract Renal Cell Carcinoma (RCC) is diagnosed in approximately 65,000 people
annually in the United States, accounting for~ 3% of all human cancers. The death rate for …