Atypical/Nor98 scrapie cases in sheep were diagnosed for the first time in Norway in 1998.
They are now identified in small ruminants in most European countries and represent an …

Prions cause fatal and transmissible neurodegenerative disease. These etiological
infectious agents are formed in greater part from a misfolded cell-surface protein called …

Scrapie in small ruminants belongs to transmissible spongiform encephalopathies (TSEs),
or prion diseases, a family of fatal neurodegenerative disorders that affect humans and …

Prions arise when the cellular prion protein (PrPC) undergoes a self-propagating
conformational change; the resulting infectious conformer is designated PrPSc. Frequently …

Transmissible spongiform encephalopathies (TSEs) in animals include, among others,
bovine spongiform encephalopathy (BSE), scrapie, chronic wasting disease, and atypical …

Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a fatal group of
infectious, inherited and spontaneous neurodegenerative diseases affecting human and …

The aim of this study was to analyze the epidemiology and prion protein (PrP) genetics in
scrapie-affected sheep flocks in Germany. For this purpose, 224 German scrapie cases in …

Background The development of active surveillance programmes for transmissible
spongiform encephalopathies of small ruminants across Europe has led to the recent …

Great Britain and elsewhere have detected atypical scrapie infection in sheep with PrP
genotypes thought to be genetically resistant to the classical form of scrapie. DNA …

Isolates of atypical scrapie recently identified in sheep and goats in France were compared
with Nor98 isolates reported in Norway. Western blot methods for characterization of the …