Pathways of cellular proteostasis in aging and disease
Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …
Antinuclear antibodies in systemic sclerosis: an update
A Stochmal, J Czuwara, M Trojanowska… - Clinical reviews in allergy …, 2020 - Springer
Systemic sclerosis is an autoimmune disease characterized by fibrosis of skin and internal
organs, vasculopathy, and dysregulation of immune system. A diagnostically important …
organs, vasculopathy, and dysregulation of immune system. A diagnostically important …
Protein disaggregation in multicellular organisms
NB Nillegoda, AS Wentink, B Bukau - Trends in biochemical sciences, 2018 - cell.com
Protein aggregates are formed in cells with profoundly perturbed proteostasis, where the
generation of misfolded proteins exceeds the cellular refolding and degradative capacity …
generation of misfolded proteins exceeds the cellular refolding and degradative capacity …
The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors
H Wang, B Li, L Zuo, B Wang, Y Yan, K Tian… - Nature …, 2022 - nature.com
Abstract RNA polymerase II (Pol II) apparatuses are compartmentalized into transcriptional
clusters. Whether protein factors control these clusters remains unknown. In this study, we …
clusters. Whether protein factors control these clusters remains unknown. In this study, we …
The role of pontin and reptin in cellular physiology and cancer etiology
YQ Mao, WA Houry - Frontiers in molecular biosciences, 2017 - frontiersin.org
Pontin (RUVBL1, TIP49, TIP49a, Rvb1) and Reptin (RUVBL2, TIP48, TIP49b, Rvb2) are
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …
A first order phase transition mechanism underlies protein aggregation in mammalian cells
The formation of misfolded protein aggregates is a hallmark of neurodegenerative diseases.
The aggregate formation process exhibits an initial lag phase when precursor clusters …
The aggregate formation process exhibits an initial lag phase when precursor clusters …
Protein aggregation and disaggregation in cells and development
Protein aggregation is a feature of numerous neurodegenerative diseases. However,
regulated, often reversible, formation of protein aggregates, also known as condensates …
regulated, often reversible, formation of protein aggregates, also known as condensates …
Biomolecular assemblies: moving from observation to predictive design
Biomolecular assembly is a key driving force in nearly all life processes, providing structure,
information storage, and communication within cells and at the whole organism level. These …
information storage, and communication within cells and at the whole organism level. These …
RUVBL1/RUVBL2 ATPase activity drives PAQosome maturation, DNA replication and radioresistance in lung cancer
Summary RUVBL1 and RUVBL2 (collectively RUVBL1/2) are essential AAA+ ATPases that
function as co-chaperones and have been implicated in cancer. Here we investigated the …
function as co-chaperones and have been implicated in cancer. Here we investigated the …
Prions, chaperones, and proteostasis in yeast
TA Chernova, KD Wilkinson… - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Prions are alternatively folded, self-perpetuating protein isoforms involved in a variety of
biological and pathological processes. Yeast prions are protein-based heritable elements …
biological and pathological processes. Yeast prions are protein-based heritable elements …