Mechanisms of vascular aging

Z Ungvari, S Tarantini, AJ Donato, V Galvan… - Circulation …, 2018 - Am Heart Assoc
Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Effects and mechanisms of resveratrol on aging and age‐related diseases

DD Zhou, M Luo, SY Huang, A Saimaiti… - Oxidative medicine …, 2021 - Wiley Online Library
The aging of population has become an issue of great concern because of its rapid
increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be …

Endothelial cell metabolism

G Eelen, P de Zeeuw, L Treps, U Harjes… - Physiological …, 2018 - journals.physiology.org
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Hypertension-induced cognitive impairment: from pathophysiology to public health

Z Ungvari, P Toth, S Tarantini, CI Prodan… - Nature Reviews …, 2021 - nature.com
Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial …

P Toth, S Tarantini, A Csiszar… - American Journal of …, 2017 - journals.physiology.org
Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

Effective inhibition of MERS-CoV infection by resveratrol

SC Lin, CT Ho, WH Chuo, S Li, TT Wang… - BMC infectious diseases, 2017 - Springer
Abstract Background Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an
emerging viral pathogen that causes severe morbidity and mortality. Up to date, there is no …

Impaired neurovascular coupling in aging and Alzheimer's disease: contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

S Tarantini, CHT Tran, GR Gordon, Z Ungvari… - Experimental …, 2017 - Elsevier
The importance of (micro) vascular contributions to cognitive impairment and dementia
(VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age …

[HTML][HTML] Bioactive natural compounds against human coronaviruses: a review and perspective

Y **an, J Zhang, Z Bian, H Zhou, Z Zhang, Z Lin… - … Pharmaceutica Sinica B, 2020 - Elsevier
Coronaviruses (CoVs), a family of enveloped positive-sense RNA viruses, are characterized
by club-like spikes that project from their surface, unusually large RNA genome, and unique …

Obesity and aging: Molecular mechanisms and therapeutic approaches

AL Santos, S Sinha - Ageing Research Reviews, 2021 - Elsevier
The epidemic of obesity is a major challenge for health policymakers due to its far-reaching
effects on population health and potentially overwhelming financial burden on healthcare …

[HTML][HTML] Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and …

S Tarantini, MN Valcarcel-Ares, P Toth… - Redox biology, 2019 - Elsevier
Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling
(NVC) has an essential role in maintenance of healthy cognitive function. In aging increased …