Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …

Goat domestication was critical for agriculture and civilization, but its underlying genetic
changes and selection regimes remain unclear. Here, we analyze the genomes of …

Present-day Tibetans have adapted both genetically and culturally to the high altitude
environment of the Tibetan Plateau, but fundamental questions about their origins remain …

High altitudes (> 8,000 ft or 2,500 m) provide an experiment of nature for measuring
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …

Humans and their domestic animals have lived and thrived in high-altitude environments
worldwide for thousands of years. These populations have developed a number of …

Both genomics-and proteomics-based investigations have identified several essential
genes, proteins, and pathways that may facilitate human adaptive genotype/phenotype in a …

Hypoxia-inducible factor pathway genes are linked to adaptation in both human and
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated …

Recent studies suggest that admixture with archaic hominins played an important role in
facilitating biological adaptations to new environments. For example, interbreeding with …

Erythrocytosis, or increased production of red blood cells, is one of the most well-
documented physiological traits that varies within and among in high-altitude populations …