Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …
the detection limit of clinical assays. However, some individuals experience persistent …
Origin and functional role of antisense transcription in endogenous and exogenous retroviruses
F Romerio - Retrovirology, 2023 - Springer
Most proteins expressed by endogenous and exogenous retroviruses are encoded in the
sense (positive) strand of the genome and are under the control of regulatory elements …
sense (positive) strand of the genome and are under the control of regulatory elements …
Activation of HIV-1 proviruses increases downstream chromatin accessibility
It is unclear how the activation of HIV-1 transcription affects chromatin structure. We
interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites …
interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites …
Identification and map** of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells
The human immunodeficiency virus type 1 (HIV-1) encodes multiple RNA molecules.
Transcripts that originate from the proviral 5′ long terminal repeat (LTR) function as …
Transcripts that originate from the proviral 5′ long terminal repeat (LTR) function as …
Extending the coding potential of viral genomes with overlap** antisense ORFs: a case for the de novo creation of the gene encoding the antisense protein ASP of …
A Pavesi, F Romerio - Viruses, 2022 - mdpi.com
Gene overprinting occurs when point mutations within a genomic region with an existing
coding sequence create a new one in another reading frame. This process is quite frequent …
coding sequence create a new one in another reading frame. This process is quite frequent …
Creation of the HIV-1 antisense gene asp coincided with the emergence of the pandemic group M and is associated with faster disease progression
A Pavesi, F Romerio - Microbiology Spectrum, 2024 - Am Soc Microbiol
Despite being first identified more than three decades ago, the antisense gene asp of HIV-1
remains an enigma. asp is present uniquely in pandemic (group M) HIV-1 strains, and it is …
remains an enigma. asp is present uniquely in pandemic (group M) HIV-1 strains, and it is …
Retroviral Antisense Transcripts and Genes: 33 Years after First Predicted, a Silent Retroviral Revolution?
Paradigm shifts throughout the history of microbiology have typically been ignored, or met
with skepticism and resistance, by the scientific community. This has been especially true in …
with skepticism and resistance, by the scientific community. This has been especially true in …
In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals
Natural antisense transcripts are expressed in eukaryotes, prokaryotes, and viruses and can
possess regulatory functions at the transcriptional and/or post-transcriptional levels. In vitro …
possess regulatory functions at the transcriptional and/or post-transcriptional levels. In vitro …
Covariation of amino acid substitutions in the HIV-1 envelope glycoprotein gp120 and the antisense protein ASP associated with coreceptor usage
A Pavesi, F Romerio - bioRxiv, 2025 - biorxiv.org
The tropism of the Human Immunodeficiency Virus type 1 (HIV-1) is determined by the use of
either or both of the chemokine coreceptors CCR5 (R5) or CXCR4 (X4) for entry into the …
either or both of the chemokine coreceptors CCR5 (R5) or CXCR4 (X4) for entry into the …
[PDF][PDF] Virus-host interactions in HIV-1 and HIV-2 infections
E Johansson - 2023 - portal.research.lu.se
Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are the two causative
agents of AIDS. HIV-1 is responsible for the HIV pandemic, while HIV-2 is primarily confined …
agents of AIDS. HIV-1 is responsible for the HIV pandemic, while HIV-2 is primarily confined …