Gliomas are the most common central nervous system tumors. New technologies, including
genetic research and advanced statistical methods, revolutionize the therapeutic approach …

Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …

BACKGROUND AND PURPOSE: The World Health Organization has recently placed new
emphasis on the integration of genetic information for gliomas. While tissue sampling …

Diffuse gliomas are up till now graded based upon morphology. Recent findings indicate
that isocitrate dehydrogenase (IDH) mutation status defines biologically distinct groups of …

Background. High-grade gliomas with mutations in the isocitrate dehydrogenase (IDH) gene
family confer longer overall survival relative to their IDH-wild-type counterparts. Accurate …

Background Astrocytoma of the isocitrate dehydrogenase (IDH) wild-type gene is described
as a provisional entity within the new World Health Organization (WHO) classification. Some …

Background Isocitrate dehydrogenase (IDH) wildtype (wt) grade II gliomas are a rare and
heterogeneous entity. Survival and prognostic factors are poorly defined. Methods We …

Primary brain tumors, most commonly gliomas, are histopathologically typed and graded as
World Health Organization (WHO) grades I–IV according to increasing degrees of …

The new 2016 WHO brain tumor classification defines different diffuse gliomas primarily
according to the presence or absence of IDH mutations (IDH-mt) and combined 1p/19q loss …

Importance Over the past 4 years, our understanding of gliomagenesis and the practice of
neuro-oncology have been radically changed by the discovery of mutations involving the …