The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle
progression during mitosis with the state of chromosome attachment to the mitotic spindle …

The spindle checkpoint ensures proper chromosome segregation during cell division.
Unravelling checkpoint signalling has been a long-standing challenge owing to the …

Class IA phosphoinositide 3-kinases (PI3Ks) are a family of p85/p110 heterodimeric lipid
kinases that generate second messenger signals downstream of tyrosine kinases, thereby …

Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of
subsequent cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 …

Cancer cells contain abnormal number of chromosomes (aneuploidy), which is a prevalent
form of genetic instability in human cancers. Defects in a cell cycle surveillance mechanism …

Accurate chromosome segregation relies on the precise regulation of mitotic progression.
Regulation involves control over the timing of mitosis and a spindle assembly checkpoint …

Chromosome segregation is a complex and astonishingly accurate process whose inner
working is beginning to be understood at the molecular level. The spindle checkpoint plays …

During mitosis, the recruitment of spindle-checkpoint-associated proteins to the kinetochore
occurs in a defined order. The protein kinase Bub1 localizes to the kinetochore very early …

Here we show that suppression of synthesis of the microtubule motor CENP-E (centromere-
associated protein E), a component of the kinetochore corona fibres of mammalian …

The mitotic checkpoint acts to inhibit entry into anaphase until all chromosomes have
successfully attached to spindle microtubules. Unattached kinetochores are believed to …